Combined Treatment with Diazepam and Allopregnanolone Reverses Tetramethylenedisulfotetramine (TETS)-induced Calcium Dysregulation in Cultured Neurons and Protects TETS-intoxicated Mice Against Lethal Seizures

Tetramethylenedisulfotetramine (TETS) is a potent convulsant GABA(A) receptor blocker. Mice receiving a lethal dose of TETS (0.15 mg/kg i.p.) are rescued from death by a high dose of diazepam (5 mg/kg i.p.) administered shortly after the second clonic seizure (∼20 min post-TETS). However, this high...

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Détails bibliographiques
Publié dans:Neuropharmacology
Auteurs principaux: Bruun, Donald A., Cao, Zhengyu, Inceoglu, Bora, Vito, Stephen T., Austin, Adam T., Hulsizer, Susan, Hammock, Bruce D., Tancredi, Daniel J., Rogawski, Michael A., Pessah, Isaac N., Lein, Pamela J.
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4466064/
https://ncbi.nlm.nih.gov/pubmed/25882826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2015.03.035
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