Comparison of the toxicokinetics of the convulsants picrotoxinin and tetramethylenedisulfotetramine (TETS) in mice

Acute intoxication with picrotoxin or the rodenticide tetramethylenedisulfotetramine (TETS) can cause seizures that rapidly progress to status epilepticus and death. Both compounds inhibit γ-aminobutyric acid type-A (GABA(A)) receptors with similar potency. However, TETS is approximately 100 × more...

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Detalhes bibliográficos
Publicado no:Arch Toxicol
Main Authors: Pressly, Brandon, Vasylieva, Natalia, Barnych, Bogdan, Singh, Vikrant, Singh, Latika, Bruun, Donald A., Hwang, Sung Hee, Chen, Yi-Je, Fettinger, James C., Johnnides, Stephanie, Lein, Pamela J., Yang, Jun, Hammock, Bruce D., Wulff, Heike
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2020
Assuntos:
Toxicokinetics and Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7303059/
https://ncbi.nlm.nih.gov/pubmed/32239239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-020-02728-z
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