Comparison of the toxicokinetics of the convulsants picrotoxinin and tetramethylenedisulfotetramine (TETS) in mice

Acute intoxication with picrotoxin or the rodenticide tetramethylenedisulfotetramine (TETS) can cause seizures that rapidly progress to status epilepticus and death. Both compounds inhibit γ-aminobutyric acid type-A (GABA(A)) receptors with similar potency. However, TETS is approximately 100 × more...

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Bibliografiske detaljer
Udgivet i:Arch Toxicol
Main Authors: Pressly, Brandon, Vasylieva, Natalia, Barnych, Bogdan, Singh, Vikrant, Singh, Latika, Bruun, Donald A., Hwang, Sung Hee, Chen, Yi-Je, Fettinger, James C., Johnnides, Stephanie, Lein, Pamela J., Yang, Jun, Hammock, Bruce D., Wulff, Heike
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2020
Fag:
Toxicokinetics and Metabolism
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7303059/
https://ncbi.nlm.nih.gov/pubmed/32239239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-020-02728-z
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