Comparison of the toxicokinetics of the convulsants picrotoxinin and tetramethylenedisulfotetramine (TETS) in mice

Acute intoxication with picrotoxin or the rodenticide tetramethylenedisulfotetramine (TETS) can cause seizures that rapidly progress to status epilepticus and death. Both compounds inhibit γ-aminobutyric acid type-A (GABA(A)) receptors with similar potency. However, TETS is approximately 100 × more...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Arch Toxicol
Päätekijät: Pressly, Brandon, Vasylieva, Natalia, Barnych, Bogdan, Singh, Vikrant, Singh, Latika, Bruun, Donald A., Hwang, Sung Hee, Chen, Yi-Je, Fettinger, James C., Johnnides, Stephanie, Lein, Pamela J., Yang, Jun, Hammock, Bruce D., Wulff, Heike
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Springer Berlin Heidelberg 2020
Aiheet:
Toxicokinetics and Metabolism
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7303059/
https://ncbi.nlm.nih.gov/pubmed/32239239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-020-02728-z
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