Combined Treatment with Diazepam and Allopregnanolone Reverses Tetramethylenedisulfotetramine (TETS)-induced Calcium Dysregulation in Cultured Neurons and Protects TETS-intoxicated Mice Against Lethal Seizures

Tetramethylenedisulfotetramine (TETS) is a potent convulsant GABA(A) receptor blocker. Mice receiving a lethal dose of TETS (0.15 mg/kg i.p.) are rescued from death by a high dose of diazepam (5 mg/kg i.p.) administered shortly after the second clonic seizure (∼20 min post-TETS). However, this high...

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Detaylı Bibliyografya
Yayımlandı:Neuropharmacology
Asıl Yazarlar: Bruun, Donald A., Cao, Zhengyu, Inceoglu, Bora, Vito, Stephen T., Austin, Adam T., Hulsizer, Susan, Hammock, Bruce D., Tancredi, Daniel J., Rogawski, Michael A., Pessah, Isaac N., Lein, Pamela J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4466064/
https://ncbi.nlm.nih.gov/pubmed/25882826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2015.03.035
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