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Combined Treatment with Diazepam and Allopregnanolone Reverses Tetramethylenedisulfotetramine (TETS)-induced Calcium Dysregulation in Cultured Neurons and Protects TETS-intoxicated Mice Against Lethal Seizures
Tetramethylenedisulfotetramine (TETS) is a potent convulsant GABA(A) receptor blocker. Mice receiving a lethal dose of TETS (0.15 mg/kg i.p.) are rescued from death by a high dose of diazepam (5 mg/kg i.p.) administered shortly after the second clonic seizure (∼20 min post-TETS). However, this high...
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| 出版年: | Neuropharmacology |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2015
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4466064/ https://ncbi.nlm.nih.gov/pubmed/25882826 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2015.03.035 |
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