Post-Exposure Administration of Diazepam Combined with Soluble Epoxide Hydrolase Inhibition Stops Seizures and Modulates Neuroinflammation in a Murine Model of Acute TETS Intoxication

Tetramethylenedisulfotetramine (TETS) is a potent convulsant poison for which there is currently no approved antidote. The convulsant action of TETS is thought to be mediated by inhibition of type A gamma-aminobutyric acid receptor (GABA(A)R) function. We, therefore, investigated the effects of post...

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Detalhes bibliográficos
Publicado no:Toxicol Appl Pharmacol
Main Authors: Vito, Stephen T., Austin, Adam T., Banks, Christopher N., Inceoglu, Bora, Bruun, Donald A., Zolkowska, Dorota, Tancredi, Daniel J., Rogawski, Michael A., Hammock, Bruce D., Lein, Pamela J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258121/
https://ncbi.nlm.nih.gov/pubmed/25448683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2014.10.001
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