Identification of telomere dysfunction in Friedreich ataxia

BACKGROUND: Friedreich ataxia (FRDA) is a progressive inherited neurodegenerative disorder caused by mutation of the FXN gene, resulting in decreased frataxin expression, mitochondrial dysfunction and oxidative stress. A recent study has identified shorter telomeres in FRDA patient leukocytes as a p...

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Gepubliceerd in:Mol Neurodegener
Hoofdauteurs: Anjomani Virmouni, Sara, Al-Mahdawi, Sahar, Sandi, Chiranjeevi, Yasaei, Hemad, Giunti, Paola, Slijepcevic, Predrag, Pook, Mark A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2015
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4462004/
https://ncbi.nlm.nih.gov/pubmed/26059974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-015-0019-6
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