Epigenetic-based therapies for Friedreich ataxia

Friedreich ataxia (FRDA) is a lethal autosomal recessive neurodegenerative disorder caused primarily by a homozygous GAA repeat expansion mutation within the first intron of the FXN gene, leading to inhibition of FXN transcription and thus reduced frataxin protein expression. Recent studies have sho...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Sandi, Chiranjeevi, Sandi, Madhavi, Anjomani Virmouni, Sara, Al-Mahdawi, Sahar, Pook, Mark A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2014
Gaiak:
Genetics
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4042889/
https://ncbi.nlm.nih.gov/pubmed/24917884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2014.00165
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