Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leuekmia

From an shRNA screen, we identified ClpP as a member of the mitochondrial proteome whose knockdown reduced the viability of K562 leukemic cells. Expression of this mitochondrial protease that has structural similarity to the cytoplasmic proteosome is increased in the leukemic cells from approximatel...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Cancer Cell
Κύριοι συγγραφείς: Cole, Alicia, Wang, Zezhou, Coyaud, Etienne, Voisin, Veronique, Gronda, Marcela, Jitkova, Yulia, Mattson, Rachel, Hurren, Rose, Babovic, Sonja, Maclean, Neil, Restall, Ian, Wang, Xiaoming, Jeyaraju, Danny V., Sukhai, Mahadeo A., Prabha, Swayam, Bashir, Shaheena, Ramakrishnan, Ashwin, Leung, Elisa, Qia, Yi Hua, Zhang, Nianxian, Combes, Kevin R., Ketela, Troy, Lin, Fengshu, Houry, Walid A., Aman, Ahmed, Al-awar, Rima, Zheng, Wei, Wienholds, Erno, Xu, Chang Jiang, Dick, John, Wang, Jean C.Y., Moffat, Jason, Minden, Mark D., Eaves, Connie J., Bader, Gary D., Hao, Zhenyue, Kornblau, Steven M., Raught, Brian, Schimmer, Aaron D.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2015
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4461837/
https://ncbi.nlm.nih.gov/pubmed/26058080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2015.05.004
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