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Fractional killing arises from cell-to-cell variability in overcoming a caspase activity threshold
When cells are exposed to death ligands such as TRAIL, a fraction undergoes apoptosis and a fraction survives; if surviving cells are re-exposed to TRAIL, fractional killing is once again observed. Therapeutic antibodies directed against TRAIL receptors also cause fractional killing, even at saturat...
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| Udgivet i: | Mol Syst Biol |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BlackWell Publishing Ltd
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4461398/ https://ncbi.nlm.nih.gov/pubmed/25953765 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20145584 |
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