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Stochastic fluctuations in apoptotic threshold of tumour cells can enhance apoptosis and combat fractional killing

Fractional killing, which is a significant impediment to successful chemotherapy, is observed even in a population of genetically identical cancer cells exposed to apoptosis-inducing agents. This phenomenon arises not from genetic mutation but from cell-to-cell variation in the activation timing and...

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Publicat a:R Soc Open Sci
Autors principals: Qiu, Baohua, Zhou, Tianshou, Zhang, Jiajun
Format: Artigo
Idioma:Inglês
Publicat: The Royal Society 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7062090/
https://ncbi.nlm.nih.gov/pubmed/32257298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsos.190462
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