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Stochastic fluctuations in apoptotic threshold of tumour cells can enhance apoptosis and combat fractional killing
Fractional killing, which is a significant impediment to successful chemotherapy, is observed even in a population of genetically identical cancer cells exposed to apoptosis-inducing agents. This phenomenon arises not from genetic mutation but from cell-to-cell variation in the activation timing and...
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| Publicado no: | R Soc Open Sci |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Royal Society
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7062090/ https://ncbi.nlm.nih.gov/pubmed/32257298 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsos.190462 |
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