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Cells surviving fractional killing by TRAIL exhibit transient but sustainable resistance and inflammatory phenotypes

When clonal populations of human cells are exposed to apoptosis-inducing agents, some cells die and others survive. This fractional killing arises not from mutation but from preexisting, stochastic differences in the levels and activities of proteins regulating apoptosis. Here we examine the propert...

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Detalhes bibliográficos
Main Authors: Flusberg, Deborah A., Roux, Jérémie, Spencer, Sabrina L., Sorger, Peter K.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3708725/
https://ncbi.nlm.nih.gov/pubmed/23699397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E12-10-0737
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