Intracellular oligomeric amyloid-beta rapidly regulates GluA1 subunit of AMPA receptor in the hippocampus

The acute neurotoxicity of oligomeric forms of amyloid-β 1-42 (Aβ) is implicated in the pathogenesis of Alzheimer’s disease (AD). However, how these oligomers might first impair neuronal function at the onset of pathology is poorly understood. Here we have examined the underlying toxic effects cause...

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Udgivet i:Sci Rep
Main Authors: Whitcomb, Daniel J., Hogg, Ellen L., Regan, Philip, Piers, Thomas, Narayan, Priyanka, Whitehead, Garry, Winters, Bryony L., Kim, Dong-Hyun, Kim, Eunjoon, St George-Hyslop, Peter, Klenerman, David, Collingridge, Graham L., Jo, Jihoon, Cho, Kwangwook
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4460729/
https://ncbi.nlm.nih.gov/pubmed/26055072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep10934
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