Amyloid-β oligomers unveil a novel primate model of sporadic Alzheimer's disease

par Jebelli, Joseph D., Piers, Thomas M.
Publié dans Front Neurosci (2015)

Selective Depletion of Microglia from Cerebellar Granule Cell Cultures Using L-leucine Methyl Ester

par Jebelli, Joseph, Piers, Thomas, Pocock, Jennifer
Publié dans J Vis Exp (2015)

Translational Concepts of mGluR5 in Synaptic Diseases of the Brain

par Piers, Thomas M., Kim, Dong Hyun, Kim, Byeong C., Regan, Philip, Whitcomb, Daniel J., Cho, Kwangwook
Publié 2012

The influence of the R47H triggering receptor expressed on myeloid cells 2 variant on microglial exosome profiles

par Mallach, Anna, Gobom, Johan, Zetterberg, Henrik, Hardy, John, Piers, Thomas M, Wray, Selina, Pocock, Jennifer M
Publié dans Brain Commun (2021)

A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC‐derived microglia

par Piers, Thomas M., Cosker, Katharina, Mallach, Anna, Johnson, Gabriel Thomas, Guerreiro, Rita, Hardy, John, Pocock, Jennifer M.
Publié dans FASEB J (2019)

Soluble Fibrinogen Triggers Non-cell Autonomous ER Stress-Mediated Microglial-Induced Neurotoxicity

par Piers, Thomas M., East, Emma, Villegas-Llerena, Claudio, Sevastou, Ioanna G., Matarin, Mar, Hardy, John, Pocock, Jennifer M.
Publié dans Front Cell Neurosci (2018)

Postsynaptic p47phox regulates long-term depression in the hippocampus

par Yi, Jee Hyun, Kim, Dong Hyun, Piers, Thomas M., Kim, Seung Chan, Whitcomb, Daniel J., Regan, Philip, Cho, Kwangwook
Publié dans Cell Discov (2018)

Microglial signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate inability to activate inflammasome

par Cosker, Katharina, Mallach, Anna, Limaye, Janhavi, Piers, Thomas M., Staddon, James, Neame, Stephen J., Hardy, John, Pocock, Jennifer M.
Publié dans Sci Rep (2021)

Abrogation of LRRK2 dependent Rab10 phosphorylation with TLR4 activation and alterations in evoked cytokine release in immune cells

par Nazish, Iqra, Arber, Charles, Piers, Thomas M., Warner, Thomas T., Hardy, John A., Lewis, Patrick A., Pocock, Jennifer M., Bandopadhyay, Rina
Publié dans Neurochem Int (2021)

Tau Phosphorylation at Serine 396 Residue Is Required for Hippocampal LTD

par Regan, Philip, Piers, Thomas, Yi, Jee-Hyun, Kim, Dong-Hyun, Huh, Seonghoo, Park, Se Jin, Ryu, Jong Hoon, Whitcomb, Daniel J., Cho, Kwangwook
Publié dans J Neurosci (2015)

The Trem2 R47H Alzheimer’s risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans

par Xiang, Xianyuan, Piers, Thomas M., Wefers, Benedikt, Zhu, Kaichuan, Mallach, Anna, Brunner, Bettina, Kleinberger, Gernot, Song, Wilbur, Colonna, Marco, Herms, Jochen, Wurst, Wolfgang, Pocock, Jennifer M., Haass, Christian
Publié dans Mol Neurodegener (2018)

Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF)

par Kailainathan, Sumangali, Piers, Thomas M., Yi, Jee Hyun, Choi, Seongmin, Fahey, Mark S., Borger, Eva, Gunn-Moore, Frank J., O’Neill, Laurie, Lever, Michael, Whitcomb, Daniel J., Cho, Kwangwook, Allen, Shelley J.
Publié dans Pharmacol Res (2016)

Microtubule-associated protein tau is essential for long-term depression in the hippocampus

par Kimura, Tetsuya, Whitcomb, Daniel J., Jo, Jihoon, Regan, Philip, Piers, Thomas, Heo, Seonghoo, Brown, Christopher, Hashikawa, Tsutomu, Murayama, Miyuki, Seok, Heon, Sotiropoulos, Ioannis, Kim, Eunjoon, Collingridge, Graham L., Takashima, Akihiko, Cho, Kwangwook
Publié 2014

Intracellular oligomeric amyloid-beta rapidly regulates GluA1 subunit of AMPA receptor in the hippocampus

par Whitcomb, Daniel J., Hogg, Ellen L., Regan, Philip, Piers, Thomas, Narayan, Priyanka, Whitehead, Garry, Winters, Bryony L., Kim, Dong-Hyun, Kim, Eunjoon, St George-Hyslop, Peter, Klenerman, David, Collingridge, Graham L., Jo, Jihoon, Cho, Kwangwook
Publié dans Sci Rep (2015)

Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis

par Garcia-Reitboeck, Pablo, Phillips, Alexandra, Piers, Thomas M., Villegas-Llerena, Claudio, Butler, Matt, Mallach, Anna, Rodrigues, Celia, Arber, Charles E., Heslegrave, Amanda, Zetterberg, Henrik, Neumann, Harald, Neame, Stephen, Houlden, Henry, Hardy, John, Pocock, Jennifer M.
Publié dans Cell Rep (2018)

Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions

par Liu, Wenfei, Taso, Orjona, Wang, Rui, Bayram, Sevinc, Graham, Andrew C, Garcia-Reitboeck, Pablo, Mallach, Anna, Andrews, William D, Piers, Thomas M, Botia, Juan A, Pocock, Jennifer M, Cummings, Damian M, Hardy, John, Edwards, Frances A, Salih, Dervis A
Publié dans Hum Mol Genet (2020)

Acute stress causes rapid synaptic insertion of Ca(2+)-permeable AMPA receptors to facilitate long-term potentiation in the hippocampus

par Whitehead, Garry, Jo, Jihoon, Hogg, Ellen L., Piers, Thomas, Kim, Dong-Hyun, Seaton, Gillian, Seok, Heon, Bru-Mercier, Gilles, Son, Gi Hoon, Regan, Philip, Hildebrandt, Lars, Waite, Eleanor, Kim, Byeong-Chae, Kerrigan, Talitha L., Kim, Kyungjin, Whitcomb, Daniel J., Collingridge, Graham L., Lightman, Stafford L., Cho, Kwangwook
Publié 2013