Abrogation of LRRK2 dependent Rab10 phosphorylation with TLR4 activation and alterations in evoked cytokine release in immune cells

LRRK2 protein is expressed prominently in immune cells, cell types whose contribution to LRRK2-associated genetic Parkinson’s disease (PD) is increasingly being recognised. We investigated the effect of inflammatory stimuli using RAW264.7 murine macrophage cells as model systems. A detailed time cou...

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Detalhes bibliográficos
Publicado no:Neurochem Int
Main Authors: Nazish, Iqra, Arber, Charles, Piers, Thomas M., Warner, Thomas T., Hardy, John A., Lewis, Patrick A., Pocock, Jennifer M., Bandopadhyay, Rina
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610942/
https://ncbi.nlm.nih.gov/pubmed/34004238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuint.2021.105070
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