Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration

BACKGROUND: Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial and sporadic Parkinson’s disease (PD). Elevated kinase activity is associated with LRRK2 toxicity, but the substrates that mediate neurodegeneration remain poorly defined. Given the increasing evidenc...

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Detalhes bibliográficos
Publicado no:Mol Neurodegener
Main Authors: Jeong, Ga Ram, Jang, Eun-Hae, Bae, Jae Ryul, Jun, Soyoung, Kang, Ho Chul, Park, Chi-Hu, Shin, Joo-Ho, Yamamoto, Yukio, Tanaka-Yamamoto, Keiko, Dawson, Valina L., Dawson, Ted M., Hur, Eun-Mi, Lee, Byoung Dae
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5811984/
https://ncbi.nlm.nih.gov/pubmed/29439717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-018-0240-1
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