Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration

BACKGROUND: Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial and sporadic Parkinson’s disease (PD). Elevated kinase activity is associated with LRRK2 toxicity, but the substrates that mediate neurodegeneration remain poorly defined. Given the increasing evidenc...

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Vydáno v:Mol Neurodegener
Hlavní autoři: Jeong, Ga Ram, Jang, Eun-Hae, Bae, Jae Ryul, Jun, Soyoung, Kang, Ho Chul, Park, Chi-Hu, Shin, Joo-Ho, Yamamoto, Yukio, Tanaka-Yamamoto, Keiko, Dawson, Valina L., Dawson, Ted M., Hur, Eun-Mi, Lee, Byoung Dae
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5811984/
https://ncbi.nlm.nih.gov/pubmed/29439717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-018-0240-1
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