Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms

Autosomal dominant mutations in LRRK2 that enhance kinase activity cause Parkinson's disease. LRRK2 phosphorylates a subset of Rab GTPases including Rab8A and Rab10 within its effector binding motif. Here, we explore whether LRRK1, a less studied homolog of LRRK2 that regulates growth factor re...

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Библиографические подробности
Опубликовано в: :Biochem J
Главные авторы: Malik, Asad U., Karapetsas, Athanasios, Nirujogi, Raja S., Mathea, Sebastian, Chatterjee, Deep, Pal, Prosenjit, Lis, Pawel, Taylor, Matthew, Purlyte, Elena, Gourlay, Robert, Dorward, Mark, Weidlich, Simone, Toth, Rachel, Polinski, Nicole K., Knapp, Stefan, Tonelli, Francesca, Alessi, Dario R.
Формат: Artigo
Язык:Inglês
Опубликовано: Portland Press Ltd. 2021
Предметы:
Signaling
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7886321/
https://ncbi.nlm.nih.gov/pubmed/33459343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20200937
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