Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms

Autosomal dominant mutations in LRRK2 that enhance kinase activity cause Parkinson's disease. LRRK2 phosphorylates a subset of Rab GTPases including Rab8A and Rab10 within its effector binding motif. Here, we explore whether LRRK1, a less studied homolog of LRRK2 that regulates growth factor re...

詳細記述

保存先:
書誌詳細
出版年:Biochem J
主要な著者: Malik, Asad U., Karapetsas, Athanasios, Nirujogi, Raja S., Mathea, Sebastian, Chatterjee, Deep, Pal, Prosenjit, Lis, Pawel, Taylor, Matthew, Purlyte, Elena, Gourlay, Robert, Dorward, Mark, Weidlich, Simone, Toth, Rachel, Polinski, Nicole K., Knapp, Stefan, Tonelli, Francesca, Alessi, Dario R.
フォーマット: Artigo
言語:Inglês
出版事項: Portland Press Ltd. 2021
主題:
Signaling
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7886321/
https://ncbi.nlm.nih.gov/pubmed/33459343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20200937
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