Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis

We previously reported that Parkinson’s disease (PD) kinase LRRK2 phosphorylates a subset of Rab GTPases on a conserved residue in their switch-II domains (Steger et al., 2016) (PMID: 26824392). Here, we systematically analyzed the Rab protein family and found 14 of them (Rab3A/B/C/D, Rab5A/B/C, Rab...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Steger, Martin, Diez, Federico, Dhekne, Herschel S, Lis, Pawel, Nirujogi, Raja S, Karayel, Ozge, Tonelli, Francesca, Martinez, Terina N, Lorentzen, Esben, Pfeffer, Suzanne R, Alessi, Dario R, Mann, Matthias
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2017
Assuntos:
Biochemistry and Chemical Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5695910/
https://ncbi.nlm.nih.gov/pubmed/29125462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31012
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