Učitavanje...
Membrane association but not identity is required for LRRK2 activation and phosphorylation of Rab GTPases
LRRK2 kinase mutations cause familial Parkinson’s disease and increased phosphorylation of a subset of Rab GTPases. Rab29 recruits LRRK2 to the trans-Golgi and activates it there, yet some of LRRK2’s major Rab substrates are not on the Golgi. We sought to characterize the cell biology of LRRK2 activ...
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| Izdano u: | J Cell Biol |
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| Glavni autori: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Rockefeller University Press
2019
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6891090/ https://ncbi.nlm.nih.gov/pubmed/31624137 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201902184 |
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