Membrane association but not identity is required for LRRK2 activation and phosphorylation of Rab GTPases

LRRK2 kinase mutations cause familial Parkinson’s disease and increased phosphorylation of a subset of Rab GTPases. Rab29 recruits LRRK2 to the trans-Golgi and activates it there, yet some of LRRK2’s major Rab substrates are not on the Golgi. We sought to characterize the cell biology of LRRK2 activ...

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Bibliografiske detaljer
Udgivet i:J Cell Biol
Main Authors: Gomez, Rachel C., Wawro, Paulina, Lis, Pawel, Alessi, Dario R., Pfeffer, Suzanne R.
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2019
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6891090/
https://ncbi.nlm.nih.gov/pubmed/31624137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201902184
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