Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF)

This study describes a fundamental functional difference between the two main polymorphisms of the pro-form of brain-derived neurotrophic factor (proBDNF), providing an explanation as to why these forms have such different age-related neurological outcomes. Healthy young carriers of the Met66 form (...

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Pubblicato in:Pharmacol Res
Autori principali: Kailainathan, Sumangali, Piers, Thomas M., Yi, Jee Hyun, Choi, Seongmin, Fahey, Mark S., Borger, Eva, Gunn-Moore, Frank J., O’Neill, Laurie, Lever, Michael, Whitcomb, Daniel J., Cho, Kwangwook, Allen, Shelley J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4773404/
https://ncbi.nlm.nih.gov/pubmed/26687096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2015.12.008
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