Precursor of Brain-derived Neurotrophic Factor (proBDNF) Forms a Complex with Huntingtin-associated Protein-1 (HAP1) and Sortilin That Modulates proBDNF Trafficking, Degradation, and Processing

proBDNF, a precursor of brain-derived neurotrophic factor (BDNF), is anterogradely transported and released from nerve terminals, but the mechanism underlying this process remains unclear. In this study, we report that proBDNF forms a complex with Huntingtin associated protein-1 (HAP1) and sortilin,...

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Autores principales: Yang, Miao, Lim, Yoon, Li, Xiaojiang, Zhong, Jin-Hua, Zhou, Xin-Fu
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Neurobiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3091234/
https://ncbi.nlm.nih.gov/pubmed/21357693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.195347
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