A Novel Peptide Interfering with proBDNF-Sortilin Interaction Alleviates Chronic Inflammatory Pain

Rationale: Brain-derived neurotrophic factor (BDNF) is a key mediator in the development of chronic pain. Sortilin is known to interact with proBDNF and regulate its activity-dependent secretion in cortical neurons. In a rat model of inflammatory pain with intraplantar injection of complete Freund&#...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Ho, Idy H.T., Liu, Xiaodong, Zou, Yidan, Liu, Taian, Hu, Wei, Chan, Hung, Tian, Yuanyuan, Zhang, Yuchen, Li, Qing, Kou, Shanglong, Chan, Chee Sam, Gin, Tony, Cheng, Christopher H.K., Wong, Sunny H., Yu, Jun, Zhang, Lin, Wu, William K.K., Chan, Matthew T.V.
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6485195/
https://ncbi.nlm.nih.gov/pubmed/31037129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.29703
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