Neuronal release of proBDNF

Pro–brain-derived neurotrophic factor (proBDNF) and mature BDNF utilize distinct receptors to mediate divergent neuronal actions. Using new tools to quantitate endogenous BDNF isoforms, we found that mouse neurons secrete both proBDNF and mature BDNF. The highest levels of proBDNF and p75 were obser...

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Bibliografiske detaljer
Main Authors: Yang, Jianmin, Siao, Chia-Jen, Nagappan, Guhan, Marinic, Tina, Jing, Deqiang, McGrath, Kelly, Chen, Zhe-Yu, Mark, Willie, Tessarollo, Lino, Lee, Francis S, Lu, Bai, Hempstead, Barbara L
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737352/
https://ncbi.nlm.nih.gov/pubmed/19136973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2244
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