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Control of extracellular cleavage of ProBDNF by high frequency neuronal activity

Pro- and mature neurotrophins often elicit opposing biological effects. For example, mature brain-derived neurotrophic factor (mBDNF) is critical for long-term potentiation induced by high-frequency stimulation, whereas proBDNF facilitate long-term depression induced by low-frequency stimulation. Be...

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Détails bibliographiques
Auteurs principaux: Nagappan, Guhan, Zaitsev, Eugene, Senatorov, Vladimir V., Yang, Jianmin, Hempstead, Barbara L., Lu, Bai
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2009
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2633536/
https://ncbi.nlm.nih.gov/pubmed/19147841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0807322106
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