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Control of extracellular cleavage of ProBDNF by high frequency neuronal activity
Pro- and mature neurotrophins often elicit opposing biological effects. For example, mature brain-derived neurotrophic factor (mBDNF) is critical for long-term potentiation induced by high-frequency stimulation, whereas proBDNF facilitate long-term depression induced by low-frequency stimulation. Be...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2633536/ https://ncbi.nlm.nih.gov/pubmed/19147841 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0807322106 |
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