Activity-Dependent Ubiquitination of GluA1 and GluA2 Regulates AMPA Receptor Intracellular Sorting and Degradation

AMPA receptors (AMPARs) have recently been shown to undergo post-translational ubiquitination in mammalian neurons. However, the underlying molecular mechanisms are poorly understood and remain controversial. Here, we report that all four AMPAR subunits (GluA1–4) are rapidly ubiquitinated upon brief...

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Udgivet i:Cell Rep
Main Authors: Widagdo, Jocelyn, Chai, Ye Jin, Ridder, Margreet C., Chau, Yu Qian, Johnson, Richard C., Sah, Pankaj, Huganir, Richard L., Anggono, Victor
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524782/
https://ncbi.nlm.nih.gov/pubmed/25660027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.01.015
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