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AMPA receptor pHluorin-GluA2 reports NMDA receptor-induced intracellular acidification in hippocampal neurons

NMDA receptor activation promotes endocytosis of AMPA receptors, which is an important mechanism underlying long-term synaptic depression. The pH-sensitive GFP variant pHluorin fused to the N terminus of GluA2 (pH-GluA2) has been used to assay NMDA-mediated AMPA receptor endocytosis and recycling. H...

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Detalhes bibliográficos
Main Authors: Rathje, Mette, Fang, Huaqiang, Bachman, Julia L., Anggono, Victor, Gether, Ulrik, Huganir, Richard L., Madsen, Kenneth L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3761605/
https://ncbi.nlm.nih.gov/pubmed/23940334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1312982110
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