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Endophilin2 Interacts with GluA1 to Mediate AMPA Receptor Endocytosis Induced by Oligomeric Amyloid-β

Amyloid-β (Aβ) plays an important role in Alzheimer’s disease (AD), as oligomeric Aβ induces loss of postsynaptic AMPA receptors (AMPARs) leading to cognitive deficits. The loss of postsynaptic AMPARs is mediated through the clathrin-dependent endocytosis pathway, in which endophilin2 is one of the...

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書誌詳細
主要な著者: Jifeng Zhang, Yichen Yin, Zhisheng Ji, Zhenbin Cai, Bo Zhao, Jiong Li, Minghui Tan, Guoqing Guo
フォーマット: Artigo
言語:Inglês
出版事項: Hindawi Limited 2017-01-01
シリーズ:Neural Plasticity
オンライン・アクセス:http://dx.doi.org/10.1155/2017/8197085
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