VEGF-B promotes cancer metastasis through a VEGF-A–independent mechanism and serves as a marker of poor prognosis for cancer patients

The biological functions of VEGF-B in cancer progression remain poorly understood. Here, we report that VEGF-B promotes cancer metastasis through the remodeling of tumor microvasculature. Knockdown of VEGF-B in tumors resulted in increased perivascular cell coverage and impaired pulmonary metastasis...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Yang, Xiaojuan, Zhang, Yin, Hosaka, Kayoko, Andersson, Patrik, Wang, Jian, Tholander, Fredrik, Cao, Ziquan, Morikawa, Hiromasa, Tegnér, Jesper, Yang, Yunlong, Iwamoto, Hideki, Lim, Sharon, Cao, Yihai
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4460438/
https://ncbi.nlm.nih.gov/pubmed/25991856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1503500112
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