Dual roles of endothelial FGF-2–FGFR1–PDGF-BB and perivascular FGF-2–FGFR2–PDGFRβ signaling pathways in tumor vascular remodeling

Perivascular cells are important cellular components in the tumor microenvironment (TME) and they modulate vascular integrity, remodeling, stability, and functions. Here we show using mice models that FGF-2 is a potent pericyte-stimulating factor in tumors. Mechanistically, FGF-2 binds to FGFR2 to s...

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Publicat a:Cell Discov
Autors principals: Hosaka, Kayoko, Yang, Yunlong, Nakamura, Masaki, Andersson, Patrik, Yang, Xiaojuan, Zhang, Yin, Seki, Takahiro, Scherzer, Martin, Dubey, Olivier, Wang, Xinsheng, Cao, Yihai
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798893/
https://ncbi.nlm.nih.gov/pubmed/29423271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41421-017-0002-1
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