Dual roles of endothelial FGF-2–FGFR1–PDGF-BB and perivascular FGF-2–FGFR2–PDGFRβ signaling pathways in tumor vascular remodeling

Perivascular cells are important cellular components in the tumor microenvironment (TME) and they modulate vascular integrity, remodeling, stability, and functions. Here we show using mice models that FGF-2 is a potent pericyte-stimulating factor in tumors. Mechanistically, FGF-2 binds to FGFR2 to s...

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Detalhes bibliográficos
Publicado no:Cell Discov
Main Authors: Hosaka, Kayoko, Yang, Yunlong, Nakamura, Masaki, Andersson, Patrik, Yang, Xiaojuan, Zhang, Yin, Seki, Takahiro, Scherzer, Martin, Dubey, Olivier, Wang, Xinsheng, Cao, Yihai
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798893/
https://ncbi.nlm.nih.gov/pubmed/29423271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41421-017-0002-1
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