Dual roles of endothelial FGF-2–FGFR1–PDGF-BB and perivascular FGF-2–FGFR2–PDGFRβ signaling pathways in tumor vascular remodeling

Perivascular cells are important cellular components in the tumor microenvironment (TME) and they modulate vascular integrity, remodeling, stability, and functions. Here we show using mice models that FGF-2 is a potent pericyte-stimulating factor in tumors. Mechanistically, FGF-2 binds to FGFR2 to s...

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Detaylı Bibliyografya
Yayımlandı:Cell Discov
Asıl Yazarlar: Hosaka, Kayoko, Yang, Yunlong, Nakamura, Masaki, Andersson, Patrik, Yang, Xiaojuan, Zhang, Yin, Seki, Takahiro, Scherzer, Martin, Dubey, Olivier, Wang, Xinsheng, Cao, Yihai
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798893/
https://ncbi.nlm.nih.gov/pubmed/29423271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41421-017-0002-1
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