Discontinuation of anti-VEGF cancer therapy promotes metastasis through a liver revascularization mechanism

The impact of discontinuation of anti-VEGF cancer therapy in promoting cancer metastasis is unknown. Here we show discontinuation of anti-VEGF treatment creates a time-window of profound structural changes of liver sinusoidal vasculatures, exhibiting hyper-permeability and enlarged open-pore sizes o...

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Pubblicato in:Nat Commun
Autori principali: Yang, Yunlong, Zhang, Yin, Iwamoto, Hideki, Hosaka, Kayoko, Seki, Takahiro, Andersson, Patrik, Lim, Sharon, Fischer, Carina, Nakamura, Masaki, Abe, Mitsuhiko, Cao, Renhai, Skov, Peter Vilhelm, Chen, Fang, Chen, Xiaoyun, Lu, Yongtian, Nie, Guohui, Cao, Yihai
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5025794/
https://ncbi.nlm.nih.gov/pubmed/27580750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12680
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