PTEN expression as a Predictor of Response to Focal Adhesion Kinase Inhibition in Uterine Cancer

PTEN is known to be frequently mutated in uterine cancer and also dephosphorylates FAK. Here, we examined the impact of PTEN alterations on the response to treatment with a FAK inhibitor (GSK2256098). In vitro and in vivo therapeutic experiments were carried out using PTEN mutated and PTEN-wild type...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Mol Cancer Ther
Κύριοι συγγραφείς: Thanapprapasr, Duangmani, Previs, Rebecca A., Hu, Wei, Ivan, Cristina, Armaiz-Pena, Guillermo N., Dorniak, Piotr L., Hansen, Jean M., Rupaimoole, Rajesha, Huang, Jie, Dalton, Heather J., Ali-Fehmi, Rouba, Coleman, Robert L., Sood, Anil K.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2015
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458384/
https://ncbi.nlm.nih.gov/pubmed/25833835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-1077
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