PTEN expression as a Predictor of Response to Focal Adhesion Kinase Inhibition in Uterine Cancer

PTEN is known to be frequently mutated in uterine cancer and also dephosphorylates FAK. Here, we examined the impact of PTEN alterations on the response to treatment with a FAK inhibitor (GSK2256098). In vitro and in vivo therapeutic experiments were carried out using PTEN mutated and PTEN-wild type...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Thanapprapasr, Duangmani, Previs, Rebecca A., Hu, Wei, Ivan, Cristina, Armaiz-Pena, Guillermo N., Dorniak, Piotr L., Hansen, Jean M., Rupaimoole, Rajesha, Huang, Jie, Dalton, Heather J., Ali-Fehmi, Rouba, Coleman, Robert L., Sood, Anil K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458384/
https://ncbi.nlm.nih.gov/pubmed/25833835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-1077
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