PTEN expression as a Predictor of Response to Focal Adhesion Kinase Inhibition in Uterine Cancer

PTEN is known to be frequently mutated in uterine cancer and also dephosphorylates FAK. Here, we examined the impact of PTEN alterations on the response to treatment with a FAK inhibitor (GSK2256098). In vitro and in vivo therapeutic experiments were carried out using PTEN mutated and PTEN-wild type...

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書誌詳細
出版年:Mol Cancer Ther
主要な著者: Thanapprapasr, Duangmani, Previs, Rebecca A., Hu, Wei, Ivan, Cristina, Armaiz-Pena, Guillermo N., Dorniak, Piotr L., Hansen, Jean M., Rupaimoole, Rajesha, Huang, Jie, Dalton, Heather J., Ali-Fehmi, Rouba, Coleman, Robert L., Sood, Anil K.
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458384/
https://ncbi.nlm.nih.gov/pubmed/25833835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-1077
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