Role of YAP1 as a Marker of Sensitivity to Dual AKT and P70S6K Inhibition in Ovarian and Uterine Malignancies

Background:The PI3K/AKT/P70S6K pathway is an attractive therapeutic target in ovarian and uterine malignancies because of its high rate of deregulation and key roles in tumor growth. Here, we examined the biological effects of MSC2363318A, which is a novel inhibitor of AKT1, AKT3, and P70S6K. Method...

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Publicado en:J Natl Cancer Inst
Main Authors: Previs, Rebecca A., Armaiz-Pena, Guillermo N., Ivan, Cristina, Dalton, Heather J., Rupaimoole, Rajesha, Hansen, Jean M., Lyons, Yasmin, Huang, Jie, Haemmerle, Monika, Wagner, Michael J., Gharpure, Kshipra M., Nagaraja, Archana S., Filant, Justyna, McGuire, Michael H., Noh, Kyunghee, Dorniak, Piotr L., Linesch, Sarah L., Mangala, Lingegowda S., Pradeep, Sunila, Wu, Sherry Y., Sood, Anil K.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2017
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6059189/
https://ncbi.nlm.nih.gov/pubmed/28376174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djw296
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