Role of YAP1 as a Marker of Sensitivity to Dual AKT and P70S6K Inhibition in Ovarian and Uterine Malignancies

Background:The PI3K/AKT/P70S6K pathway is an attractive therapeutic target in ovarian and uterine malignancies because of its high rate of deregulation and key roles in tumor growth. Here, we examined the biological effects of MSC2363318A, which is a novel inhibitor of AKT1, AKT3, and P70S6K. Method...

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Publicado no:J Natl Cancer Inst
Main Authors: Previs, Rebecca A., Armaiz-Pena, Guillermo N., Ivan, Cristina, Dalton, Heather J., Rupaimoole, Rajesha, Hansen, Jean M., Lyons, Yasmin, Huang, Jie, Haemmerle, Monika, Wagner, Michael J., Gharpure, Kshipra M., Nagaraja, Archana S., Filant, Justyna, McGuire, Michael H., Noh, Kyunghee, Dorniak, Piotr L., Linesch, Sarah L., Mangala, Lingegowda S., Pradeep, Sunila, Wu, Sherry Y., Sood, Anil K.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6059189/
https://ncbi.nlm.nih.gov/pubmed/28376174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djw296
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