New Treatment Opportunities in Phosphatase and Tensin Homolog (PTEN)-Deficient Tumors: Focus on PTEN/Focal Adhesion Kinase Pathway

Deep genetic studies revealed that phosphatase and tensin homolog (PTEN) mutations or loss of expression are not early events in cancer development but characterize tumor progression and invasion. Loss of PTEN function causes a full activation of the prosurvival phosphoinositide 3-kinase (PI3K)/AKT/...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Front Oncol
Autori principali: Alfieri, Roberta, Giovannetti, Elisa, Bonelli, Mara, Cavazzoni, Andrea
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2017
Soggetti:
Oncology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5552661/
https://ncbi.nlm.nih.gov/pubmed/28848709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2017.00170
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