Opa1 Overexpression Ameliorates the Phenotype of Two Mitochondrial Disease Mouse Models

Increased levels of the mitochondria-shaping protein Opa1 improve respiratory chain efficiency and protect from tissue damage, suggesting that it could be an attractive target to counteract mitochondrial dysfunction. Here we show that Opa1 overexpression ameliorates two mouse models of defective mit...

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Publicat a:Cell Metab
Autors principals: Civiletto, Gabriele, Varanita, Tatiana, Cerutti, Raffaele, Gorletta, Tatiana, Barbaro, Serena, Marchet, Silvia, Lamperti, Costanza, Viscomi, Carlo, Scorrano, Luca, Zeviani, Massimo
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457891/
https://ncbi.nlm.nih.gov/pubmed/26039449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.04.016
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