Opa1 Overexpression Ameliorates the Phenotype of Two Mitochondrial Disease Mouse Models

Increased levels of the mitochondria-shaping protein Opa1 improve respiratory chain efficiency and protect from tissue damage, suggesting that it could be an attractive target to counteract mitochondrial dysfunction. Here we show that Opa1 overexpression ameliorates two mouse models of defective mit...

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Bibliografische gegevens
Gepubliceerd in:Cell Metab
Hoofdauteurs: Civiletto, Gabriele, Varanita, Tatiana, Cerutti, Raffaele, Gorletta, Tatiana, Barbaro, Serena, Marchet, Silvia, Lamperti, Costanza, Viscomi, Carlo, Scorrano, Luca, Zeviani, Massimo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cell Press 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457891/
https://ncbi.nlm.nih.gov/pubmed/26039449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.04.016
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