Opa1 Overexpression Protects from Early-Onset Mpv17(−/−)-Related Mouse Kidney Disease

Moderate overexpression of Opa1, the master regulator of mitochondrial cristae morphology, significantly improved mitochondrial damage induced by drugs, surgical denervation, or oxidative phosphorylation (OXPHOS) defects due to specific impairment of a single mitochondrial respiratory chain complex....

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Detalles Bibliográficos
Publicado en:Mol Ther
Main Authors: Luna-Sanchez, Marta, Benincá, Cristiane, Cerutti, Raffaele, Brea-Calvo, Gloria, Yeates, Anna, Scorrano, Luca, Zeviani, Massimo, Viscomi, Carlo
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Gene & Cell Therapy 2020
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7403474/
https://ncbi.nlm.nih.gov/pubmed/32562616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.06.010
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