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In Vivo Correction of COX Deficiency by Activation of the AMPK/PGC-1α Axis
Increased mitochondrial biogenesis by activation of PPAR- or AMPK/PGC-1α-dependent homeostatic pathways has been proposed as a treatment for mitochondrial disease. We tested this hypothesis on three recombinant mouse models characterized by defective cytochrome c-oxidase (COX) activity: a knockout (...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cell Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3130927/ https://ncbi.nlm.nih.gov/pubmed/21723506 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2011.04.011 |
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