Rapamycin rescues mitochondrial myopathy via coordinated activation of autophagy and lysosomal biogenesis

The mTOR inhibitor rapamycin ameliorates the clinical and biochemical phenotype of mouse, worm, and cellular models of mitochondrial disease, via an unclear mechanism. Here, we show that prolonged rapamycin treatment improved motor endurance, corrected morphological abnormalities of muscle, and incr...

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Bibliografische gegevens
Gepubliceerd in:EMBO Mol Med
Hoofdauteurs: Civiletto, Gabriele, Dogan, Sukru Anil, Cerutti, Raffaele, Fagiolari, Gigliola, Moggio, Maurizio, Lamperti, Costanza, Benincá, Cristiane, Viscomi, Carlo, Zeviani, Massimo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2018
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Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6220341/
https://ncbi.nlm.nih.gov/pubmed/30309855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201708799
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