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Rapamycin rescues mitochondrial myopathy via coordinated activation of autophagy and lysosomal biogenesis
The mTOR inhibitor rapamycin ameliorates the clinical and biochemical phenotype of mouse, worm, and cellular models of mitochondrial disease, via an unclear mechanism. Here, we show that prolonged rapamycin treatment improved motor endurance, corrected morphological abnormalities of muscle, and incr...
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| Gepubliceerd in: | EMBO Mol Med |
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| Hoofdauteurs: | , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
John Wiley and Sons Inc.
2018
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6220341/ https://ncbi.nlm.nih.gov/pubmed/30309855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201708799 |
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