Pneumococcal IgA1 Protease Subverts Specific Protection By Human IgA1

Bacterial IgA1 proteases may sabotage the protective effects of IgA. In vitro, both exogenous and endogenously-produced IgA1 protease inhibited phagocytic killing of Streptococcus pneumoniae by capsule-specific IgA1 human monoclonal antibodies (hMAb's), but not IgA2. These IgA1 proteases cleave...

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Bibliographic Details
Published in:Mucosal Immunol
Main Authors: Janoff, Edward N., Rubins, Jeffrey B., Fasching, Claudine, Charboneau, Darlene, Rahkola, Jeremy T., Plaut, Andrew G., Weiser, Jeffrey N.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4456019/
https://ncbi.nlm.nih.gov/pubmed/23820749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2013.41
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