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Mechanism and inhibition of Streptococcus pneumoniae IgA1 protease

Opportunistic pathogens such as Streptococcus pneumoniae secrete a giant metalloprotease virulence factor responsible for cleaving host IgA1, yet the molecular mechanism has remained unknown since their discovery nearly 30 years ago despite the potential for developing vaccines that target these enz...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Wang, Zhiming, Rahkola, Jeremy, Redzic, Jasmina S., Chi, Ying-Chih, Tran, Norman, Holyoak, Todd, Zheng, Hongjin, Janoff, Edward, Eisenmesser, Elan
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2020
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7695701/
https://ncbi.nlm.nih.gov/pubmed/33247098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19887-3
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