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Mechanism and inhibition of Streptococcus pneumoniae IgA1 protease

Opportunistic pathogens such as Streptococcus pneumoniae secrete a giant metalloprotease virulence factor responsible for cleaving host IgA1, yet the molecular mechanism has remained unknown since their discovery nearly 30 years ago despite the potential for developing vaccines that target these enz...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Wang, Zhiming, Rahkola, Jeremy, Redzic, Jasmina S., Chi, Ying-Chih, Tran, Norman, Holyoak, Todd, Zheng, Hongjin, Janoff, Edward, Eisenmesser, Elan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7695701/
https://ncbi.nlm.nih.gov/pubmed/33247098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19887-3
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