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Killing of Streptococcus pneumoniae by capsular polysaccharide–specific polymeric IgA, complement, and phagocytes

The role of IgA in the control of invasive mucosal pathogens such as Streptococcus pneumoniae is poorly understood. We demonstrate that human pneumococcal capsular polysaccharide–specific IgA initiated dose-dependent killing of S. pneumoniae with complement and phagocytes. The majority of specific I...

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Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Janoff, Edward N., Fasching, Claudine, Orenstein, Jan M., Rubins, Jeffrey B., Opstad, Nancy L., Dalmasso, Agustin P.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 1999
Sujets:
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC408571/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10525053/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI6310
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