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Killing of Streptococcus pneumoniae by capsular polysaccharide–specific polymeric IgA, complement, and phagocytes

The role of IgA in the control of invasive mucosal pathogens such as Streptococcus pneumoniae is poorly understood. We demonstrate that human pneumococcal capsular polysaccharide–specific IgA initiated dose-dependent killing of S. pneumoniae with complement and phagocytes. The majority of specific I...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Janoff, Edward N., Fasching, Claudine, Orenstein, Jan M., Rubins, Jeffrey B., Opstad, Nancy L., Dalmasso, Agustin P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC408571/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10525053/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI6310
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