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The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans
The increased longevity of the C. elegans electron transport chain mutants isp-1 and nuo-6 is mediated by mitochondrial ROS (mtROS) signaling. Here we show that the mtROS signal is relayed by the conserved, mitochondria-associated, intrinsic apoptosis signaling pathway (CED-9/Bcl2, CED-4/Apaf1 and C...
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| Publicado no: | Cell |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4454526/ https://ncbi.nlm.nih.gov/pubmed/24813612 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.02.055 |
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