CEP-1, the Caenorhabditis elegans p53 Homolog, Mediates Opposing Longevity Outcomes in Mitochondrial Electron Transport Chain Mutants

Caenorhabditis elegans CEP-1 and its mammalian homolog p53 are critical for responding to diverse stress signals. In this study, we found that cep-1 inactivation suppressed the prolonged lifespan of electron transport chain (ETC) mutants, such as isp-1 and nuo-6, but rescued the shortened lifespan o...

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Main Authors: Baruah, Aiswarya, Chang, Hsinwen, Hall, Mathew, Yuan, Jie, Gordon, Sarah, Johnson, Erik, Shtessel, Ludmila L., Yee, Callista, Hekimi, Siegfried, Derry, W. Brent, Lee, Siu Sylvia
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937132/
https://ncbi.nlm.nih.gov/pubmed/24586177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004097
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