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A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans

The nuo-6 and isp-1 genes of C. elegans encode, respectively, subunits of complex I and III of the mitochondrial respiratory chain. Partial loss-of-function mutations in these genes decrease electron transport and greatly increase the longevity of C. elegans by a mechanism that is distinct from that...

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Autori principali: Yang, Wen, Hekimi, Siegfried
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998438/
https://ncbi.nlm.nih.gov/pubmed/21151885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000556
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