Lysosomal Signaling Molecules Regulate Longevity in Caenorhabditis elegans

Lysosomes are crucial cellular organelles for human health that function in digestion and recycling of extracellular and intracellular macromolecules. We describe a signaling role for lysosomes that affects aging. In the worm, Caenorhabditis elegans, the lysosomal acid lipase LIPL-4 triggered nuclea...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Folick, Andrew, Oakley, Holly Doebbler, Yu, Yong, Armstrong, Eric H., Kumari, Manju, Sanor, Lucas, Moore, David D., Ortlund, Eric A., Zechner, Rudolf, Wang, Meng C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4425353/
https://ncbi.nlm.nih.gov/pubmed/25554789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1258857
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